Below is a list of our most recently approved projects – further information can be found by clicking on the project titles.

The IMPACT Audit: Improving the management of patients with locally advanced and recurrent rectal cancer in the UK

The IMPACT Audit is working to identify how treatment decisions are made by specialists looking after patients with complex rectal cancer, and linking these decisions to clinical and survival outcomes.
This research will provide a resource for patients, clinicians and commissioners by mapping rectal cancer services throughout the UK.

The effect of Vitamin D supplementation in patients undergoing bowel cancer surgery

A study investigating whether oral vitamin D supplements can increase vitamin D levels before and around the time of bowel cancer surgery. Hoping to lead to further research into
the effects of vitamin D supplements on reducing deaths following treatment for cancer.

FASt study (FIT in Adenoma polyp Surveillance)

A study to test if non-invasive stool and urine tests are effective in identifying patients at risk of polyps as well as testing if these polyps have potential to become cancerous. Only those with a positive stool or urine test suggesting risk of polyps will undergo a colonoscopy. Results will provide the evidence base required for use of non-invasive stool and urine testing within clinical
practice, thereby benefiting patients through early detection and avoidance of unnecessary invasive tests.

The type of bacteria involved in Crohn’s Disease anal fistula

Using microbiome analytical technology to create a detailed bacterial map of the type of bacteria involved in Crohn’s disease related fistula, and comparing them to fistula due to other causes.
Could allow for earlier identification of Crohn’s fistula, and a better understanding of how they happen in order to identify new targets for future treatment.

Improving outcomes for older people undergoing emergency abdominal surgery

Gathering detailed information on a group of elderly patients about the events leading up to hospital admission, choice of operation, what risk or fitness assessments were carried out, questionnaires about quality of life, return to previous activities, healthcare usage and cost to the NHS to explorewhat can be improved in these processes.
This study will identify which aspects of care could be improved to develop an enhanced pathway of care for elderly patients, which would then be tested in a larger trial.

Examination of Immune Cells and their association with response to therapy and survival in Colorectal Cancer

Investigating why some patients respond to immunotherapy while others do not by examining the type and functional status of immune cells in microsatellite instability colorectal cancer.
The study aims to identify biomarkers that could help doctors spot patients who would benefit from immunotherapy and direct them toward the most effective treatment.

Genomic determinants of immune response in colorectal cancer

Examining the differences in how the immune system detects cancer cells, and comparing these to genetic changes to identify genetic markers suggesting good responses to immunotherapy.
Ultimately, the study hopes to expand the number of bowel cancer patients who could benefit from immunotherapy.

Can Clove oil treat fissure in ano?

Examining the effectiveness of using clove oil to heal anal fissures. If results of this study are favourable, clove oil could be a cheap, convenient and effective treatment for a common
condition where existing treatments are only moderately effective.