The findings of a BDRF funded study, awarded funding in 2014, have been published in the Journal of Proteomics.
They suggest that acid ceramidase, a protein present in high levels in some rectal cancers but not others, appears to have an effect on whether the tumour responds well to radiotherapy or not.
Exciting results like this should lead to further work to explain the connection between radiotherapy and acid ceramidase. Ultimately, it could enable clinicians to target the protein and give treatment the best chance of working for each individual patient.
The publication is available here
Citation: D.L. Bowden, P.A. Sutton, M.A. Wall, P.V. Jithesh, R.E. Jenkins, D.H. Palmer, C.E. Goldring, J.L. Parsons, B.K. Park, N.R. Kitteringham, D. Vimalachandran,
Proteomic profiling of rectal cancer reveals acid ceramidase is implicated in radiation response,
Journal of Proteomics,
Keywords: Rectal; Cancer; Chemoradiotherapy; Response; Proteomics; Biomarker
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